Angiology

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

http://mc.manuscriptcentral.com/ang

Click here for free access to the SAGE eReference platform!

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
0003319707306141v1
0003319707306141v2
59/3/357    most recent
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Google Scholar
Right arrow Articles by Moro, L.
Right arrow Articles by Antonelli-Incalzi, R.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Moro, L.
Right arrow Articles by Antonelli-Incalzi, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
This version was published on July 1, 2008
Angiology, Vol. 59, No. 3, 357-364 (2008)
DOI: 10.1177/0003319707306141

Endothelial Dysfunction in Chronic Obstructive Pulmonary Disease

Leo Moro, MD

Area di Geriatria, Università Campus Biomedico, Rome, Italy, l.moro{at}unicampus.it

Claudio Pedone, MD, PhD, MPH

Area di Geriatria, Università Campus Biomedico, Rome, Italy

Simone Scarlata, MD

Area di Geriatria, Università Campus Biomedico, Rome, Italy

Vincenzo Malafarina, MD

Area di Geriatria, Università Campus Biomedico, Rome, Italy

Filippo Fimognari, MD

Respiratory Unit, Division of Internal Medicine, ASL Roma G-Leopoldo Parodi Delfino Hospital, Colleferro, Rome, Italy

Raffaele Antonelli-Incalzi, MD

Area di Geriatria, Università Campus Biomedico, Rome, Italy

Background: Cardiovascular diseases are prevalent in people with chronic obstructive pulmonary disease (COPD). We hypothesized that endothelial dysfunction could be a marker of the proatherogen status in COPD. Methods and results: We measured endothelial dysfunction by flow-mediated dilation (FMD) and after sublingual administration of nitroglycerin (nitrate-mediated dilation: NMD) in 44 COPD patients and 48 controls. Compared with controls COPD patients had worse mean FMD (5.4% vs 8.2%, P < .001) and NMD (12.0% vs 13.9%, P = .007). FMD was inversely related to FEV1/VC ratio (r = –0.327, P = .030). The negative association between COPD and FMD was confirmed after correction for potential confounders in a multiple linear regression model (β = –0.019, P = .002). In the same model NMD (β = 0.396, P < .001) was positively associated with FMD. Conclusions: Endothelial-dependent and, to a lesser extent, endothelial-independent dilations are significantly impaired in COPD, and the impairment is proportional to the severity of bronchial obstruction.

Key Words: endothelial dysfunction • COPD • atherosclerosis


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?